3-(3,4-Dichlorophenyl)-5-(1H-indol-5-yl)-1,2,4-oxadiazole

نویسندگان

چکیده

3-(3,4-Dichlorophenyl)-5-(1H-indol-5-yl)-1,2,4-oxadiazole was synthesized via the condensation of 3,4-dichlorobenzamidoxime and methyl 1H-indole-5-carboxylate using a superbasic medium (NaOH/DMSO). The compound tested as potential inhibitor human monoamine oxidase (MAO) A B. It demonstrated notable inhibition with an IC50 value 0.036 μM for MAO-B isoform specificity. product characterized by 1H-NMR, 13C-NMR, HRMS. In conclusion, new active may serve candidate future discovery therapeutic agents neurodegenerative disorders such Parkinson’s disease.

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ژورنال

عنوان ژورنال: Molbank

سال: 2023

ISSN: ['1422-8599']

DOI: https://doi.org/10.3390/m1552